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The myotendinous junction (MTJ) acts as a bridge between muscle and tendon; yet its high stiffness relative to muscle fibers renders the tissue susceptible to injuries due to eccentric loading disparities. The limited regenerative capacity of MTJ tissue and potential for postsurgical scarring and reinjury necessitates complementary therapeutics that can enhance cellular interactions, restore mechanical properties, and support tissue rehabilitation. This review explores various approaches to engineer the MTJ utilizing biomaterial scaffolds and cellularized materials that mimic structure and function. While biomimetic materials show promise, challenges remain due to the interface’s complexity and differing patient- and location-specific structure–function characteristics, necessitating further research to address these gaps. This review also highlights the importance of studying MTJ injuries in women’s health and craniofacial reconstruction. Furthermore, engineered MTJ models provide versatile platforms for investigating trauma and degeneration, thus offering potential for advancing research across multiple fields, shedding light on interactions at tissue interfaces, and shaping the future of MTJ rehabilitation.